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Moreover, the indole core is substituted at R3 with a carbonyl group which is also bonded into a napthalene moeity. Napthalene can be a bicyclic construction of two fused benzene rings. This carbonyl bridge of JWH-018 classifies it as a ketone. JWH-018 can be an analog of THJ-018, wherein the Main indazole structure is substituted having an indole